Paroxetine in human milk

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Paroxetine in human milk.

AIMS The primary aims of the study were to estimate the exposure of infants to paroxetine via breast milk and to determine the maternal milk:plasma ratio (M/P) of paroxetine. Secondary aims were to compare single point and area under the curve (AUC) estimates of M/P, to assess variability of M/P in fore and hind milk, and to compare the observed M/P with that predicted by a model. METHODS Two...

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Paroxetine in human breast milk and nursing infants.

OBJECTIVE The purpose of this study was to determine the extent of infant medication exposure through breast-feeding during maternal treatment with paroxetine. METHOD Breast milk and paired maternal and infant sera were collected after 10 days of maternal treatment with paroxetine at a stable daily dose (10-50 mg/day). All samples were analyzed by means of high-performance liquid chromatograp...

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LEVELS AND PREDICTORS OF MACRONUTRIENTS IN MATURE HUMAN MILK

Background & Aims: Breastfeeding is an important public health strategy due to its benefits in reducing the morbidity and mortality of infants and helping to control health care costs. Breastfeeding with various macronutrients and micronutrients plays its nutritional and biological roles in optimal growth and development of the infant. Based on the importance of breastfeeding, this study aimed...

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Prostaglandins in human milk.

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Milk proteins are a complex and diverse source of biological activities. Beyond their function, intact milk proteins also act as carriers of encrypted functional sequences that, when released as peptides, exert biological functions, including antimicrobial and immunomodulatory activity, which could contribute to the infant's competitive success. Research has now revealed that the release of the...

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 1999

ISSN: 0306-5251

DOI: 10.1046/j.1365-2125.1999.00992.x